Ncoa1 ELISA Kit for Mouse(Mus musculus) | EIAab.comNcoa1 ELISA Kit for Mouse(Mus musculus)

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Ncoa1 (Gene name),

Nuclear receptor coactivator 1 (Protein name ), NCOA1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ncoa1(Src1);

Protein name:

Nuclear receptor coactivator 1(NCoA-1);

Alternative:

Steroid receptor coactivator 1(SRC-1);Nuclear receptor coactivator protein 1(mNRC-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with NCOA6 and NCOA2. Interacts with the FDL motif of STAT5A and STAT5B. Interacts with the LXXLL motif of STAT6. Interacts with STAT3 following IL-6 stimulation. Interacts with the basal transcription factor GTF2B. Interacts with COPS5, NR3C1, PCAF and TTLL5/STAMP. Interacts with the histone acetyltransferases EP300 and CREBBP, and the methyltransferase CARM1. Interacts with PSMB9. Interacts with UBE2L3; they functionally interact to regulate progesterone receptor transcriptional activity. Interacts with PRMT2.

Function:

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1447

Sequence:

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1447:

DVQCTVNLVG | GDPYLNQPGP | LGTQKPTSGP | QTPQAQQKSL | LQQLLTE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

mmu:17977

SMR:

P70365

Pfam:

PF07469

String:

P70365

UniGene:

Mm.301039

Uniprot:

P70365

FOR

ELISA Kit for Mouse NCoA-1

Cat.:

E0335h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse NCoA-1

Cat.:

E0335p

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MSDS:

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Packing:

96T

ELISA Kit for Mouse NCoA-1

Cat.:

E0335m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse NCoA-1

Cat.:

U0335p

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse NCoA-1

Cat.:

U0335m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse NCoA-1

Cat.:

U0335h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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Polyclonal Antibody for Mouse NCoA-1

Cat.:

P0335Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse NCoA-1

Cat.:

P0335Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse NCoA-1

Monoclonal Antibody for Mouse NCoA-1

Protein for Mouse NCoA-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors."
Kamei Y. , Xu L. , Heinzel T. , Torchia J. , Kurokawa R. , Gloss B. , Lin S.-C. , Heyman R.A. , Rose D.W. , Glass C.K. , Rosenfeld M.G.
Cell85:403-414(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH EP300 AND CREBBP
2.

"Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma."
Zhu Y. , Qi C. , Calandra C. , Rao M.S. , Reddy J.K.
Gene Expr.6:185-195(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"The nuclear hormone receptor coactivator SRC-1 is a specific target of p300."
Yao T.-P. , Ku G. , Zhou N. , Scully R. , Livingston D.M.
Proc. Natl. Acad. Sci. U.S.A.93:10626-10631(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH EP300 AND RAR
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain: C57BL/6J.
tissue: Cerebellum.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4)
strain: C57BL/6.
tissue: Brain.
tissue: Eye.
6.

Lubec G. , Sunyer B. , Chen W.-Q.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-33;IDENTIFICATION BY MASS SPECTROMETRY
strain: OF1.
tissue: Hippocampus.
7.

"The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function."
Torchia J. , Rose D.W. , Inostroza J. , Kamei Y. , Westin S. , Glass C.K. , Rosenfeld M.G.
Nature387:677-684(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE OF LXXLL MOTIFS;TISSUE SPECIFICITY;MUTAGENESIS OF 695-HIS--LEU-698 AND 756-ARG--LEU-759
8.

"Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene."
Xu J. , Qiu Y. , DeMayo F.J. , Tsai S.Y. , Tsai M.-J. , O'Malley B.W.
Science279:1922-1925(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
9.

"Regulation of transcription by a protein methyltransferase."
Chen D. , Ma H. , Hong H. , Koh S.S. , Huang S.-M. , Schurter B.T. , Aswad D.W. , Stallcup M.R.
Science284:2174-2177(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CARM1
10.

"SRC-1 and TIF2 control energy balance between white and brown adipose tissues."
Picard F. , Gehin M. , Annicotte J.-S. , Rocchi S. , Champy M.-F. , O'Malley B.W. , Chambon P. , Auwerx J.
Cell111:931-941(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"RORgammat recruits steroid receptor coactivators to ensure thymocyte survival."
Xie H. , Sadim M.S. , Sun Z.
J. Immunol.175:3800-3809(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS COACTIVATOR;INTERACTION WITH RORC
12.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-372 AND SER-702;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain."
Razeto A. , Ramakrishnan V. , Litterst C.M. , Giller K. , Griesinger C. , Carlomagno T. , Lakomek N. , Heimburg T. , Lodrini M. , Pfitzner E. , Becker S.
J. Mol. Biol.336:319-329(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 257-385 IN COMPLEX WITH STAT6

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